Pharmaceutical & Health Technology

Compound Fragment

  • 1.  Compound Fragment

    Posted 04-30-2019 16:51
    ​Hello,
    I have a patron who is trying find out if a compound fragment was part of a market drug.  I'm wondering what databases would help.  SciFinder provided no obvious hits.  Any advice would be greatly appreciated.

    Thank you!

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    Wendy Quinn-Decatur
    Librarian
    Albany Molecular Research Inc.
    518-512-2183
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  • 2.  RE: Compound Fragment

    Posted 04-30-2019 16:55
    You might consider the patent literature.  Often drugs listed in the Orange Book have a patent associated with them.  Reading the patent may give you the information.   It's not a guarantee by any means but worth a shot.

    Good luck.
    Kim

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    Kimberley Emmons
    Washington Research Fdn
    1-206-336-5600
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  • 3.  RE: Compound Fragment

    Posted 04-30-2019 16:56

    Dear Wendy,

     

    The only way I know how to search for a chemical fragment is to run a structure search in the STN Registry file.  That's pretty specific and does require access to the STN database system.

     

    Kieran

     

     

    Kieran S. Fasse

    Director, Information Services

    Law Department

    520-748-4453 (direct) • 520-748-0025 (fax)

     

    Research Corporation Technologies, Inc. • http://www.rctech.com

    6440 N. Swan Road, Suite 200 • Tucson, AZ 85718

     

     

     






  • 4.  RE: Compound Fragment

    Posted 04-30-2019 17:13
    Hello, Wendy

    Looks like you already have very good suggestions from Kimberly & Kieran. I also agree that you can approach this as a patent search beginning with the structure. On STN and besides CAS Registry (naturally ha ha), the other six (6) other structure-searchable databases. I suspect that you can initiate you search with the CAS Registry as well as Pharmaceutical Substances (PS), Derwent Drug File (DDFU) and maybe MARPAT (though for this type of search, you may not need MARPAT- as the search you're running wouldn't really be a patentability search).

    If you want to save time, you may want to run the search in PS first. Note that PS is produced by Thieme and if you do already subscribe, you can execute the search on the Thieme platform. Otherwise, you can run it via STN. If the PS comes up empty, run the search as a patent search with REG & DDFU and transfer the results to the patent literature databases like WPI, INPADOC and even CAPLUS (remember CAPLUS does include patents).

    Hopefully that helps! Good luck and have fun!

    Cheers,
    Chrissy

    ------------------------------
    Christine (Chrissy) Geluk, M.S.L.I.S.
    Principal & Founder
    Librarian At Your Service LLC
    support@librarianatyourservice.com | Chrissy@librarianatyourservice.com | Twitter @cmgeluk | Instagram @cgeluk
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  • 5.  RE: Compound Fragment

    Posted 04-30-2019 17:16

    Dear Chrissy,

     

    I don't do structure searches very often anymore and your suggestions are very informative.  Thanks from me for your response.

     

    Regards,

    Kieran

     

    Kieran S. Fasse

    Director, Information Services

    Law Department

    520-748-4453 (direct) • 520-748-0025 (fax)

     

    Research Corporation Technologies, Inc. • http://www.rctech.com

    6440 N. Swan Road, Suite 200 • Tucson, AZ 85718

     

     

     






  • 6.  RE: Compound Fragment

    Posted 05-01-2019 15:35

    Thank you everyone for the great responses!

     

     

    Wendy Quinn-Decatur, MSIS

    Librarian

    Office: (518) 512-2374

    Albany, NY

    www.amriglobal.com

       

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