Hi Amy!
Yes I agree that DailyMed is an excellent resource! I use it all the time. Just a few additional tips to Mark's suggestions with DailyMed are:
1Use the Unique Ingredient Identifier UNII code for gelatin (you'll see there's an option to search by code)
1a.To find the UNII for gelatin, go to FDA Inactive Ingredient Search at Inactive Ingredient Search for Approved Drug Products
2You can also search contraceptive* (yes asterisk is the wildcard marker in Daily Med) in the indications & usage section. Most of the contraceptives are classified as contraceptive/contraceptives in both the indications & usage section as well as the description.
3. Place the boolean NOT in the same field with the UNII (like NOT ..... in inactive ingredient unii code)
While DailyMed is your best bet but as we know, there's more than 1 way to skin a cat , lol. So if you want to explore, here's another alternative that is a bit more iterative.
1. You'll still use the UNII code for gelatin so find it from FDA Inactive Ingredient dB
2. Go to the FDALabel database (https://www.fda.gov/science-research/bioinformatics-tools/fdalabel-full-text-search-drug-product-labeling)
2a. direct link: https://nctr-crs.fda.gov/fdalabel/ui/search
3. Search contraceptive* in the Labeling section for indications & usage
4. export results
5. Refine the SAME search by searching it with the UNII code for the inactive ingredient gelatin in the Labeling, Product & Ingredient Identifiers
6. export these results
7. compare the 2 results to identify which contraceptives are NOT in 'set b'
7b. unfortunately the FDALabel dB only supports AND & OR. Hence the iterative process. lol
8. Anyway could be an interesting experiment to review .
Definitely recommend the DailyMed as it is more efficient but exploring the FDALabel could be an interesting endeavor. Good luck!
Hope that helps.
Stay safe & Cheers,
Chrissy
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Original Message:
Sent: 04-19-2023 15:55
From: Amy Nadell
Subject: Looking for inactive ingredients per drug
Thank you for great suggestions. The one that worked the best was the advanced search in Daily Med. It has numerous indexed fields for Ingredients.
See: https://dailymed.nlm.nih.gov/dailymed/advanced-search.cfm
Thank you all
Amy
Amy Nadell, MSLIS, MA, AHIP
Librarian
Banner University Medical Center Phoenix
1111 E. McDowell Road
Phoenix, AZ 85006
602.839.2384 direct
602.839.4353 main line
928.707.7671 text
Amy.nadell@bannerhealth.com
Health care made easier. Life made better.
Original Message:
Sent: 4/19/2023 3:51:00 PM
From: Mark Haythorn
Subject: RE: Looking for inactive ingredients per drug
Seems this used to be easier to do, but I checked Facts and Comparisons, Lexicomp and PDR and they've all dumbed-down their search capabilities.
Click the drop-down on the right side 'Criteria', and then scroll to find Indications. I am less than certain on this, so perhaps experiment. I used the term 'contraception' in this field, and then click the orange box that says Add.
Now go back to the criteria list, and select 'Inactive Ingredients' and then enter Gelatin. You may want to try using the Refine box and choosing NOT IN in order to find drug labels that do not have gelatin in the inactive ingredients.
You may need to play around with synonyms. For example, does CONTRACEPTIVE suffice? Or, CONTRACEPTIVE OR CONTRACEPTION? What about 'ORAL CONTRACEPTIVE' as an Indication term? I have not spent the time to see how DailyMed works with regard to plurals, term-mapping etc. Therefore, consider this an idea, and not the final answer- this search is only looking for a term in the Indications section. Perhaps there is a better way to focus just on oral contraceptives?
Example:
or
Original Message:
Sent: 4/19/2023 2:05:00 PM
From: Amy Nadell
Subject: Looking for inactive ingredients per drug
Hello,
I am hospital librarian and I have a patron is looking for an Oral Contraceptive which does not include the inactive ingredient Gelatin. Is anyone in this group aware of a database which lists excipients per drug? Or a database to search for drugs by common allergens? Or any other ideas? Since this is not my expertise, any suggestions would be helpful.
Thank you
Amy
Amy Nadell, MSLIS, MA, AHIP
<o:p></o:p>Amy.nadell@bannerhealth.com <o:p></o:p>
<o:p></o:p>
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Amy Nadell
Librarian
Banner Health
(602) 839-2384
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